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Notably, semaglutide emerged as the second best-selling drug in 2024, and in the same year, sales of tirzepatide increased 124% from the previous year [2]

Estradiol, brain insulin sensitivity and resistance The activation of estrogenic pathways exerts a neuroprotective effect in the CNS through four different mechanisms [reviewed in (53)]

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However, since the surgery is expensive, invasive, and irreversible, it is not a commonly employed approach for PCOS treatment [136]

HE and immunochemistry staining Aortic tissues including aortic roots and ascending aorta were collected for preparation of 7 m thick sections